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GLP-1, however, engages the GLP-1R/ERK1/2/HDAC6 axis to modulate downstream transcriptional activity, it lowers intracellular ROS, reduces Akt and ERK1/2 phosphorylation, restores HDAC6 expression, and thereby alleviates endothelial dysfunction and excessive autophagy (Zummo et al., 2017)
The above findings combined to demonstrate that IGF-1 is sufficient to increase collagen production in tenocytes
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In conventional medicine, many patients are prescribed immunosuppressants for autoimmune disease to dampen the overactive immune response, but can sometimes even increase the risk of infection
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