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Obesity-driven airway obstruction highlights why new sleep apnea weight loss drug therapies are being explored, as reducing fat around the airway can decrease the severity of apnea events and improve overall sleep quality
Additionally, geographic bias may limit generalizability: a potential geographic bias exists, as a substantial proportion of the included trials were conducted in North America and Europe, limiting generalizability to underrepresented populations in Asia, Africa, and South America
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Statistical significance was determined by One-Way ANOVA followed by Dunnett multiple comparison test ( b and c ) and Two-Way ANOVA with dk multiple comparison test ( e and f ), with significance indicated by asterisks (*P 0.9999 for V214A in panel b (amplitude)
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