45-55 : Highly beneficial during menopause transition
Meta-analyses pooling trial data indicated statistically significant differences favoring tirzepatide for percent weight loss, but semaglutide remained highly effective and better tolerated by some participants, notably in community practice
If OTC management fails at 6-8 weeks, a prescriber discussion about short-course metoclopramide (5-10 mg pre-meal, maximum 12 weeks) is appropriate
Can I combine semaglutide with other weight loss strategies
However, unmatched control populations and an unofficial classification of tumor stages bring bias to its results [63]
However, weight loss may alter thyroid hormone requirements, necessitating monitoring of thyroid function tests and potential dose adjustments