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A quantitative metabolomics study revealed that pancreatic stellate cells (PSCs) critically contribute to PDAC metabolic reprogramming by supporting the cancer cell tricarboxylic acid (TCA) cycle and lipid biosynthesis through autophagy-dependent alanine secretion [349]
Thus, NGF-FCS2 was selected to engineer the secreted Exe4 in hepatic cells, hereafter referred to as scExe4
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Surface of a cell and the peptide, if it's available, will bind to that receptor and then set in motion a kind of bucket brigade, a sort of conveyor belt of cellular processes
J Med Chem 58:73707380 Gotfredsen CF, Molck AM, Thorup I et al (2014) The human GLP-1 analogs liraglutide and semaglutide: absence of histopathological effects on the pancreas in nonhuman primates
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