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Of course, there's still work to be done yet: a phase 3 clinical trial is on the way, which will involve a much bigger group of participants over a longer time period
Hence, further research is needed to elucidate the effects of GLP-1-RAs and GIP-GLP-1 co-agonists on metabolic adaptation in humans post MBS
10.3109/15376516.2010.550016 24 DokumaciogluE.skenderH.AktasM.HanedanB.DokumaciogluA.SenT.et al (2017)
The emerging triple agonist retatrutide shows even greater weight loss than semaglutide or tirzepatide in early trials
The STEP clinical trial program alone involved over 4,500 participants across multiple studies
In 2024 the FDA issued a warning about a spike in overdoses and adverse side effects that was largely attributed to dosing errors with these drugs
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