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The New England Journal of Medicine, 384 (11), 989-1002
Rare but serious adverse effects include pancreatitis (though causality remains uncertain), gallbladder disease, and potential thyroid C-cell tumors (observed in rodent studies but not conclusively demonstrated in humans)
This data suggests that dose-response continues above the current standard, though regulatory approval for the higher dose is still pending
During active dose escalation, when nausea and vomiting are most common, aim for the higher end of this range
The standard titration schedule starts at 2.5 mg weekly for the first four weeks, then increases to 5 mg
Users who prioritize maximizing fat loss efficiency may prefer this formulation
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