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The complete approval process consists of five major stages: preclinical toxicology studies, Phase I human safety and tolerance testing, Phase II efficacy evaluation, Phase III large-scale controlled clinical trials, and GMP manufacturing site audits

This is why early recognition and interventions such as sleep optimization, CBT, relaxation, and graded sensory retraining are so important

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This could position it to be the metformin of obesity and become widely covered by insurance plans, opening the door to treatment for all, Horn said

Clinicians use symptom timelines and medication histories to distinguish expected metabolic shifts from signals that require urgent evaluation