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The most commonly reported adverse effects in these trials were gastrointestinal in nature including nausea, vomiting, diarrhoea, and constipation consistent with the GLP-1 receptor agonist class effect
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Compare this to tirzepatide, which can produce 22.5% total body weight loss over 72 weeks
Protein-Rich Foods: Adequate protein intake provides the necessary amino acids, including cysteine, to support glutathione synthesis
The direct cardiovascular effects represent a combination of platelet inhibition, augmented fibrinolytic responses, and attenuated thrombogenesis that collectively address not only the prothrombotic phenotypes of DM mellitus, obesity, and chronic kidney disease but a novel prevention approach beyond traditional risk factors for myocardial infarction, ischemic stroke, and cardiovascular death [90, 91]
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