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GHK without copper is noticeably cheaper but mechanistically different confirm the COA specifies the Cu-bound complex

Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization

By modulating gene expression, these peptides support wound healing and exhibit antioxidant and anti-inflammatory properties

Much of the strongest data comes from cell cultures, animal wound models and small human studies

Understanding why researchers pursued this neurotrophic compound for AD, what preclinical evidence showed, and why the clinical translation ultimately failed provides crucial context for anyone evaluating Dihexa's potential

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