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The trials produced signals consistent with the mechanism (the peptide does what its pharmacology predicts it would do), but the effect sizes were not large enough to support a successful path to drug approval as a standalone obesity treatment

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Combined Pathway Interaction When studied together, Sermorelin and Ipamorelin may influence two different regulatory systems involved in growth hormone signaling: GHRH receptor activation (Sermorelin) Ghrelin receptor activation (Ipamorelin) This dual-pathway interaction is a subject of interest in experimental endocrine research

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