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Patients may experience mild to moderate gastrointestinal symptoms, including nausea, reduced appetite, and occasional loose stools
A meta-analysis including EMPA-REG OUTCOME (empagliflozin), CANVAS Program (canagliflozin), DECLARE-TIMI 58 (dapagliflozin), CREDENCE (canagliflozin) and VERTIS CV (ertugliflozin) demonstrated that SGLT2 inhibitors reduced MACE by 10% (hazard ratio [HR] 0.90, 95% confidence interval [CI] 0.850.95) and hospitalization for heart failure by 32% (HR 0.68, 95% CI 0.610.76) compared to placebo [6]
Highlights from the July 2024 study include: Our main finding is that prescribed semaglutide is associated with an increased risk of NAION. Patients with diabetes who took semaglutide were more than four times more likely to develop NAION than those on other medications
The standard medical advice is to avoid or significantly limit alcohol consumption while taking citalopram
More recently, the FDA approved it to reduce the risk of kidney failure and heart-related death in adults with comorbidities like type 2 diabetes and chronic kidney disease
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