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Phase 2 trial data showed retatrutide producing up to 24.2 percent body weight loss at 48 weeks, compared to approximately 22.5 percent for tirzepatide at 72 weeks in the SURMOUNT-1 trial
Health Canada said at the time of the first authorization that it was reviewing eight other submissions from different companies and expected further regulatory decisions in the coming weeks and months
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The Bad Lack of FDA approval: Although compounded drugs are intended to be chemical copies of available medications, they do not have the same safety, quality, and effectiveness assurances as medications approved by the FDA
Notably, caloric restriction (CR) and moderate weight loss (approximately 510%) improve insulin sensitivity despite the accompanying loss of muscle mass, and the observed reduction appears to result primarily from increased proteolysis rather than reduced protein synthesis
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