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Until large-scale, peer-reviewed clinical trials are conducted, its use should be considered experimental

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18 Prevention Because of potential interactions from prolonged medication use, physicians should consider screening patients for vitamin B 12 deficiency if they have been taking proton pump inhibitors or H 2 blockers for more than 12 months, or metformin for more than four months

Methylcobalamin injections should be used cautiously in those patients with benzyl alcohol hypersensitivity

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