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Brown, Glutathione Redox Control of Asthma: From Molecular Mechanisms to Therapeutic Opportunities

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This signalling divergence IGF-1R-independent ERK activation vs IGF-1R-dependent Akt/mTOR activation is one of the central research questions in the MGF field and is the mechanistic basis for the functionally distinct roles of MGF (proliferation, satellite cell activation, anti-differentiation) and mature IGF-1 (differentiation, protein synthesis, hypertrophy) in the sequential muscle regeneration programme

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PMID: 9849822 Reported Bone-growth effects (preclinical) Longitudinal bone-growth rate increase without IGF-1 elevation (15-day rat study) Johansen and colleagues (Growth Horm IGF Res 1999) reported that adult female rats dosed with ipamorelin for 15 days showed a dose-dependent increase in longitudinal bone-growth rate (from 42 m/day in controls to 4452 m/day) with concurrent body-weight gain

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Malaguarnera, M., Vacante, M., Motta, M., Malaguarnera, M., Li, Volti G., and Galvano, F

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