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The majority is stored in skeletal muscle (~60%) and bone (~30%), with additional pools found in the liver (~5%), skin (~5%), pancreas, kidney and brain 22

Bij hogere doseringen neemt de efficintie van de absorptie weer af

This structural modification significantly extends its half-life and enhances resistance to proteolytic degradation, thereby enabling prolonged biological activity in vivo

Qadir et al [65] described sex-specific mechanistic differences in type 2 diabetes whereby mitochondrial failure drove beta cell dysfunction in women, whereas secretory pathway downregulation predominated in men

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