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"Tirzepatide Once Weekly for the Treatment of Obesity" (SURMOUNT-1), New England Journal of Medicine, 2022
When brain insulin signaling falters, glucose metabolism drops, oxidative stress rises, amyloid and tau processing can worsen, and microglia (the brains immune cells) are more likely to stay in an inflammatory state
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IGF-1 can be used to support maintenance of human embryonic stem cell (ESC) [3] and mesenchymal stem cell (MSC) cultures [3, 4]
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Skeletal muscles play a vital role in controlling this process
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