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Interestingly, previous studies have shown that pancreatic islets from diet-induced obese adult mice display decreased glucose-stimulated insulin secretion when treated with semaglutide, while no effect of semaglutide was detected on the islets of AIN93-fed mice [44]
In simpler terms, the immune system responds to less drug than the metabolic system needs
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Summary: Which One is Right for You
Pharmaceutics 17(8):1004, 2025
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