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In a study that compared the effects of SCS and placebo for 6 months in 60 patients with DPN refractory to medical therapy, the VAS score decreased significantly only in the SCS group (Table 2) [101]

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In type 2 diabetes, the reduced expression of HO-1 will increase the production of ROS, leading to oxidative stress and inflammatory reaction, further aggravating cell damage (Table 2)