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Entorno de sealizacin de crecimiento intracelular sostenido: Gracias a su actividad prolongada y a su unin directa al receptor, el IGF-1 LR3 genera una seal de crecimiento intracelular ms persistente en sistemas experimentales

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Sildenafil non-responders: hemodynamic and morphometric studies

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Systemic administration of a pharmacologic iron chelator reduces cartilage lesion development in the Dunkin-Hartley model of primary osteoarthritis

This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated