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Rather than mimicking GLP1 alone, it is a dual agonist that activates both GLP1 receptors and glucose-dependent insulinotropic polypeptide (GIP) receptors
First would be looking for an obesity diagnosis code
doi: 10.1146/annurev-immunol-030409-101314 113 PabstO
To assess the associations of semaglutide with recurrent CUD, the study population included 2034 patients who had active medical encounters for the diagnosis of obesity in 6/202112/2022, were for the first time (new users design) prescribed semaglutide or non-GLP-1RA anti-obesity medications during 6/202112/2022 (time zero or index event), had a diagnosis of CUD on or before the index event, and had a diagnosis of at least one of obesity-associated comorbidities on or before the index event
MC-1R is responsible for signaling the body to produce more melanin, the substance responsible for darkening skin and hair
Another unknown is what happens when large numbers of people use these drugs in the real world, outside the controlled environment of a clinical trial
