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IGF-2 can act over its own receptor (IGF-2 receptorIGF-2R), which is a manose-6-phosphate transmembrane protein with undetermined actionsit is thought that it acts as a scavenger receptor by sequestering IGF-2 and IGF-1 from the extracellular medium and targeting them for destruction [103]

[Abstract] Proc Natl Acad Sci U S A

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Am J Phys Heart Circ Phys 304:H1085H1093 Wu FT, Stefanini MO, Mac Gabhann F, Kontos CD, Annex BH, Popel AS (2010) VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model