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Because these findings are largely based on laboratory and animal studies, expected outcomes in humans are uncertain and may vary by individual, dose, and the underlying condition

Some patients may experience mild side effects, such as nausea, fatigue, or digestive changes, especially when starting treatment

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This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated

Hypothermic oxygenated perfusion in extended criteria donor liver transplantation a randomized clinical trial

doi: 10.1016/S1470-2045(15)00193-X 141