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Abstract Purpose This review focuses on the results of prospective randomized clinical trials and the conclusions from respective meta-analyses in order to summarize experiences with adjuvant selenium (Se) supplementation in Graves hyperthyroidism and orbitopathy, while identifying ambiguous findings and highlighting important open research issues

Drucker and his team had a hint that the brain might be involved for two reasons: GLP-1 receptors are abundant in there, and the brain and the immune system communicate with all organs in the body