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Adult patients with type 2 diabetes inadequately controlled on metformin (1500 mg/day) and Januvia (100 mg/day) for at least 90 days prior to screening (N=407) were randomized 1:1 to switch to once-daily Victoza 1.8 mg in addition to a Januvia placebo or continued Januvia 100 mg in addition to a Victoza placebo, both in combination with metformin

Weight Loss and Cardiovascular Outcomes Although semaglutide led to an average placebo-adjusted weight loss of 8.5% (Semaglutide arm lost 8.5% more body weight than those who took the placebo), its cardiovascular risk reduction was not linked to how much weight patients lost

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Do not try to restrict calories beyond what retatrutide naturally suppresses