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In the canonical pathway of pyroptosis, intracellular pattern recognition receptors (PRRs) recognize PAMPs (Pathogen-Associated Molecular Patterns) or Damage-Associated Molecular Patterns (DAMPs), which can activate NLR family pyrin domain-containing 3 (NLRP3) and assemble with pro-caspase-1 and adaptor protein ASC to form inflammasomes

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[1] [3] In older adults, B12 deficiency is relatively common, with prevalence increasing with age

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