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As noted earlier, in animal cells it has been shown that gliotoxin may substitute for 2-cys peroxiredoxin activity in HeLa cells by accepting electrons from NADPH via the thioredoxin reductasethioredoxin redox system to reduce H 2 O 2 to H 2 O

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Importantly, delactylase enzymes, such as HDAC1, HDAC3, and SIRT family members, have been shown to remove lactyl groups in vitro, suggesting that non-histone lactylation is dynamically reversible and may constitute a regulatory network parallel to acetylation [94]

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Expert Opinion on Drug Metabolism & Toxicology, 16 (12), 11871198

Always aim the water at the glass wall and let it trickle down gently