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This indicates that the DNMT3A-PEG-2-TGF1 pathway associated with epigenetic modifications plays an important role in diseases related to efferocytosis (Ampomah et al., 2022) (Figure 3)
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Meanwhile, targeted inhibition of the TGF- signaling axis is under active investigation with agents such as AdAPT-001 (NCT04673942) and vactosertib (NCT03732274) in sarcomas and NSCLC
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It combines L-Glutathione, the bodys master antioxidant, which helps brighten the skin and reduce pigmentation, with Vitamins C & E that protect against oxidative stress and enhance natural skin glow