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For refractory OIC in the setting of GLP-1 therapy, peripherally acting mu-opioid receptor antagonists (PAMORAs) like naloxegol (25 mg daily) may be appropriate [6]
Cervera A, Wajcberg E, Sriwijitkamol A, Fernandez M, Zuo P, Triplitt C, Musi N, DeFronzo RA, and Cersosimo E
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The possible role of -cell senescence in the development of type 2 diabetes mellitus
While certain mutationssuch as A10398G in bone metastasesexhibit strong signals of positive selection (Keith et al., 2015), the functional impact of most mtDNA variants remains inadequately validated
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