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What is supported in animal models Increased lipolysis, increased fat oxidation, decreased lipogenesis, no apparent effect on plasma glucose or insulin sensitivity, and signal that intact beta-3 adrenergic receptor activity matters for the fat-loss effect

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Also, although there was a trend toward lower muscle cell fats when combining the NNMT-inhibiting compound with exercise, the decline was not significant

Preclinical studies suggest this inhibition may protect against diet-induced weight gain and improve metabolic health