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In trials with secondary endpoints, such as STEP 9 [38], semaglutide also resulted in significant improvements in obesity-related comorbidities, including osteoarthritis-related pain and rates of reversion to normoglycaemia, further underscoring its broad clinical utility

10.1016/j.kint.2017.06.030 25 HoergerT

(August 2016)

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These restrictions and warnings demonstrate the FDAs stringent consideration of patient safety in the drug approval process