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10.1016/j.molcel.2021.09.030 49 KristensenO.KristensenL
citalopram, fluoxetine, sertraline (anxiety and depression) Drugs metabolised by CYP450 2D6: Codeine (opioid painkiller) Inducers CYP450 2C19: Rifampicin (TB) Carbamazepine (epilepsy, trigeminal neuralgia) Inhibitors CYP450 2C19: Lansoprazole, omeprazole (reflex and heartburn) Drugs metabolised by CYP450 2C19: Warfarin (anticoagulant) Diazepam (sedative, anxiolytic) Phenytoin (epilepsy) Inducers CYP450 2C9: Rifampicin (TB) Carbamazepine (epilepsy, trigeminal neuralgia) Inhibitors CYP450 2C9: Miconazole (antifungal) Fluconazole (antifungal) Drugs metabolised by CYP450 2C9: Warfarin (anticoagulant) Non-steroidal anti-inflammatories Clopidogrel (antiplatelet) Genetical variations Genetic variations can lead to altered CYP450 polymorphisms and so altered metabolism of drugs
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