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At first glucagon attracted little attention and it was not thought to have any bearing on disease
In addition, a 2024 study found that people taking another GLP-1 drug, liraglutide, had a 179% higher risk of developing NAION
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The potential for tachyphylaxis or tolerance development requires monitoring with chronic peptide therapy
Pheomelanin is lighter in color (yellow-red), so, an increase in the proportion of pheomelanin is associated with lighter skin color
Reference: Kin Wah Fung et al, GLP-1 RAs and Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Older Patients With Diabetes, JAMA Ophthalmology (2025)
10.1111/and.12925 52 OsadchukL.KleshchevM.OsadchukA
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