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When the first GLP-1 RA, exenatide, was released in 2005, the sole indication was for glycemic control, and weight loss was deemed a favorable side effect

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Aug 2018;50(6):e13033

doi: 10.2147/IMCRJ.S74563 [PubMed] 25873702 Janssen J, Singh-Saluja S

Research literature has explored its activity at melanocortin receptors and downstream signalling pathways involved in pigmentation biology

These medications are primarily prescribed to individuals with type 2 diabetes and those who are overweight or obese and have at least one weight-related health condition, such as high blood pressure or high cholesterol