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I still get headaches now and then, but ibuprofen takes care of it- which it never did before

Exenatide once weekly plus dapagliflozin once daily versus exenatide or dapagliflozin alone in patients with type 2 diabetes inadequately controlled with metformin monotherapy (DURATION-8): a 28 week, multicentre, double-blind, phase 3, randomised controlled trial

For context, the toxic dose is estimated at roughly 22,500 mg, compared to a typical weekly dose of about 6 mg

This p53 is phosphorylated on Serine 15 (p53-pS15), which prevents its degradation by MDM2 11