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In addition, the use of valproic acid with or without other anticonvulsants may cause hepatotoxicity and increase plasma ammonia concentrations, leading to encephalopathy

Younger patients who achieve substantial weight loss and demonstrate capacity for sustained dietary and exercise changes may be candidates for medication discontinuation with close monitoring

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Here are some factors to consider: Purity and Dosage: Look for supplements with a high concentration of active CLA, typically derived from safflower oil, and ensure the dosage matches clinical recommendations (usually 36 grams per day)

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