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GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically

Comp Biochem Physiol C Toxicol Pharmacol 153:175190 Lushchak VI (2011) Environmentally induced oxidative stress in aquatic animals

And therefore, its possible that a vitamin B12 deficiency in scalp tissues might play a role for people dealing with androgenic alopecia

Whether the test is positive or negative, its a good idea to speak to your healthcare provider

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Melasma is frequently associated with: Hormone changes during pregnancy Birth control medications Hormone replacement therapy Genetic predisposition Sun exposure Although melasma is not dangerous, it can be difficult to treat because UV exposure frequently triggers or worsens it