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M., Montefusco, L., Lunati, M

The short answer is that glutathione itself is recognized as safe by the FDA, but glutathione IV therapy specifically for cosmetic purposes like skin whitening is not FDA-approved

doi:10.1007/s12325-021-01710-0 Papamargaritis D, le Roux CW, Holst JJ, Davies MJ

6 One study of 100mg glutathione or 200mg glutathione nasally three times daily for three months did not note benefit over placebo, though, the study noted greater than typical improvement in the placebo group as well, which researchers noted may have acted as a confounding factor

Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia