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These issues can negatively impact patient satisfaction, treatment adherence, and healthcare provider confidence in prescribing these drugs

That "is it harming your health" question is the most practical filter for separating an aesthetic goal from a medical one, and for thinking about who might actually need a lifelong medication

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Depletion of beneficial taxa such as Odoribacter (Bacteroidetes) and Lachno Clostridium (Firmicutes), along with increased abundance of pro-inflammatory taxa including Ileibacterium and Olsenella , was associated with reduced SCFA gene expression, downregulation of tight junction proteins (occludin and claudin-1), and microglial activation in the amygdala and arcuate nucleus, indicating gut barrier disruption and neuroinflammation that coincided with anxiety-like behavior