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In those cancers relying on lipid metabolism, CD36 and other fatty acid binding proteins (FABP) are over-expressed to catch fatty acids stored in surrounding adipocytes (Koundouros and Poulogiannis, 2020)

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Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcription factor upregulating the antioxidant response element (ARE)-mediated expression of antioxidant and detoxifying enzymes, and the Nrf2-antioxidant pathway is critical in host defense against acute lung injury (ALI) 24

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Lentivirus-mediated stable VDAC1 knockdown cell lines were subsequently established ( Figure S1H ), from which EVs (EVs-shNC and EVs-shVDAC1) were isolated

doi: 10.3390/ijms19103086 51