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Other Limitations BMI can misclassify individuals as it can't differentiate between fat mass and muscle mass

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The effects of semaglutide have been proven in randomized control trials, but these trials are limited in terms of population

While a high-fat diet increases cholesterol secretion into the bile, which can lead to sludge and stone formation, 9 rapid weight loss and less frequent, low-fat meals also contribute to sludge and stone formation, as discussed later

In the dosing conditions trial, 306 subjects were screened, 161 were enrolled and randomised, 158 exposed and 151 completed the trial (Supplementary Fig