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The re-introduction of O 2 in the ischemia or long tissue hypoxia can cause aditional tissue injury (re-oxygenation injury) which is partiatly mediated by oxygen radicals (Halliwell and Gutteridge, 1989)

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Notably, the combined intervention (CIT + SVLIRT) also resulted in meaningful increases in leg lean mass and muscle strength compared with exercise alone

Biology does change and the signs are written on the skin and in the way the body feels