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In later stages, sensation and muscle loss may lead to the inability to perform even the simplest of tasks such as buttoning a shirt, tying shoes, or grasping a cane or walker

[3] Wilding, J.P., et al

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The average weight loss of 2-3 kg over 12 weeks, while statistically significant, is substantially less than results achieved with appetite-suppressing medications or intensive dietary interventions

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Manufacturers undergo regular inspections, are part of a more robust surveillance system, and are required to report and track adverse events