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While agonist peptides based on either scaffold are potent in rat obesity models 2,10,11,12,13 , only a transient weight loss effect is observed with sCT in mouse diet-induced obesity (DIO) models 14 , indicating that there may be distinctions in the mode of action of individual dual agonists

There is no known contraindication to using tirzepatide and sermorelin together, but no controlled clinical trials have evaluated this combination's safety or efficacy

Peer review Peer review information Nature Communications thanks Kathrin Ulrich and John Mieyal for their contribution to the peer review of this work

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