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Common triggers include: Sun exposure Acne and inflammation Hormonal changes (melasma) Skin irritation When tyrosinase becomes overactive, it leads to visible dark spots and uneven tone

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Several complex signal transduction pathways and cellular processes have been implicated in APAP hepatotoxicity, including those involving c-Jun N-terminal kinase, Nuclear factor E2-related factor 2 (Nrf2), p53, endoplasmic reticulum stress, autophagy, and sterile inflammation (Chowdhury et al