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Retrieved 13 September 2021

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Mikuls TR, et al

Under physiological conditions, Nfr2 is bound to kelch-like ECH-associated protein-1 (Keap1) and thereby sequestered in the cytoplasm, whereas under conditions of oxidative stress, Nfr2 dissociates from Keap1, translocates to the nucleus and induces the transcription of antioxidant enzymes

That being said, always be sure to consult with a licensed healthcare professional regarding interactions