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Badenhorst, D
Cardiovascular outcomes: In clinical studies of patients with type 2 diabetes and established heart disease, semaglutide reduced the risk of certain cardiovascular events
Featuring 94% sequence homology to endogenous human GLP-1, this 31-amino acid polypeptide incorporates two critical structural modifications: an aminoisobutyric acid (Aib) substitution at position 8 to prevent degradation by the DPP-4 enzyme, and the attachment of a C18 fatty diacid via a hydrophilic spacer
Conversion of cobalamin to AdoCbl is catalyzed by the protein encoded by the MMAB gene [methylmalonic aciduria (cobalamin deficiency) cblB type]
In clinical trials, the 12 mg maintenance dose produced 24.2% body weight loss at 48 weeks (Phase 2) and 28.7% at 68 weeks (Phase 3)
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