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Upstream regulatory mechanisms of necroptosis in DKD involve distinct epigenetic, transcriptional, and microenvironmental factors
Independent Research Fund of State Key Laboratory of Swine and Poultry Breeding Industry (20252QQZ-G51)
Studies have also indicated that heme can stimulate NLRP3 inflammasome activation in endothelial cells, inducing macrophages to produce large amounts of IL-1, which often leads to inflammatory responses in hemolytic diseases (172)
Peptidase inhibitors: DSIP degrades via amino-peptidases
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