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Among the 25 studies included in the qualitative synthesis (16 in the meta-analysis), 15 focused specifically on serum cobalamin changes (reported by baseline and post-treatment means and standard deviations in pg/mL) and 10 reported homocysteine outcomes (means and standard deviations in mmol/L)

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We've found that daily administration is common for studies investigating chronic metabolic effects over several weeks

Side effects are uncommon and usually mild, like brief soreness at the injection site

Handle in accordance with standard laboratory safety procedures