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doi: 10.26508/lsa.201900563 266 HuangYLiF

Although it was seldom reported in clinical trials, its not ruled out

living with obesity

It does not measure endotoxin levels

It is well known that HFD-induced obesity promotes low-grade hypothalamic inflammation, causing deregulation of central mechanisms that control energy homeostasis 59 , and both physical exercise and some pharmacotherapies have been shown to improve systemic metabolism by attenuating hypothalamic inflammation 60,61