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Finally, we reported causal effects indicating that the role of GLP-1 RAs in reducing the risk of depression and emotional instability may be mediated by BMI reduction, as shown in Figure 8

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With high odds ratios and wide confidence intervals, the overall odds ratios from the random effects model (104.55) and the common effect model (115.91) demonstrate a significant increase in the incidence of nausea with ROSE-010 administration ( Figure 7 )